Here is an article that reflects on that boundary between knowing and mystery. Science made beautiful by humility.
"Many people have this distorted notion that physicists know everything; or, at least, that physicists have a belief that reason can conquer all. The point I try to make is that this is not how science works at all. Quite the contrary, science is inspired by ignorance, by what we don't know about the world. Every discovery brings with it the seeds of new questions that we couldn't have contemplated before. Hence my metaphor of the Island of Knowledge, surrounded by the ocean of the unknown. Science allows us to expand the island. But the ocean remains."